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Pragmatic trials are studies designed to inform the practice of clinical trials in real life. They are usually focused on practical aspects of the study design, such as the recruitment process and consent in adherence, as well as the use of standard equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from various geographical areas. This type of heterogeneity is necessary for pragmatic trials to be valid and also helps reduce the chance of bias in the results. However excessive heterogeneity could lead to issues with the design of the trial.
Pragmatic Play is also a major player in the live casino market, offering an extensive selection of classic table games such as Blackjack and Roulette in various versions. The live studios of the company in Romania and Malta provide a genuine gaming experience for its customers, as well as an extensive selection of virtual betting options. The company also has created various interactive games to make online gambling fun. Some of these shows are telecast live and some are hosted by famous personalities from the industry.
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Pragmatic Play, a new player in the field of online casinos, has gained a reputation for its slot machines that are mobile-friendly. Their games are optimized for mobile phones, and run on HTML5 technology. They're also endorsed by trusted gaming authorities to ensure transparency and fairness. This is a great sign for players as it means the games have been tested and verified in order to guarantee the randomness and fairness of every round.
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Legality
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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are usually commissioned by policy makers and practitioners to inform their decision making. They can also be a great method of determining the cause-effect relationship between an intervention and its outcomes. However, they shouldn't be used to substitute for the use of explanation trials.
The pragmatism idea is controversial and there are doubts regarding whether pragmatic trials could be used to replace explanation tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic research study which includes recruitment, design, delivery of the intervention and its follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs), yielded 34 articles, which are shown in red in Figure 2. This is a sign that the health science community is becoming increasingly sensitized to the subject of pragmatism. It is important to keep in mind, however, that the majority were conducted in primary-care settings.